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Principal Scientist / Associate Director for Antibody, Biologic Discovery & Engineering

Company: Takeda Pharmaceutical
Location: Mount Vernon
Posted on: January 13, 2022

Job Description:

By clicking the -Apply - button, I understand that my employment application process with Takeda will commence and that the information I provide in my application will be processed in line with Takeda 's and . I further attest that all information I submit in my employment application is true to the best of my knowledge.Job DescriptionAre you looking for a patient-focused, innovation-driven company that will inspire you and empower you to shine? Join us as a Principal Scientist / Associate Director for Antibody, Biologic Discovery & Engineering in our Cambridge, MA office.At Takeda, we are transforming the pharmaceutical industry through our R&D-driven market leadership and being a values-led company. To do this, we empower our people to realize their potential through life-changing work. Certified as a Global Top Employer, we offer stimulating careers, encourage innovation, and strive for excellence in everything we do. We foster an inclusive, collaborative workplace, in which our global teams are united by an unwavering commitment to deliver Better Health and a Brighter Future to people around the world.Here, you will be a vital contributor to our inspiring, bold mission.POSITION OBJECTIVES:Takeda is committed to the long-term strategy and vision to translate science into life-changing medicines that make important differences for our patients around the world. The Global Biologics team within R&D consists of approximately 85 scientists across two US sites (Cambridge MA and San Diego, CA), and aims to discover novel therapeutic large molecule biologics serving our four main therapeutic areas Oncology, Gastroenterology, Neuroscience and Rare Disease.We are excited to pursue the search for a scientific leadership role within our Biotherapeutic Engineering team at the level of a Principal Scientist or, if you have the appropriate demonstrated experience, at the higher level of Associate Director, who will report to Director, Biotherapeutic Engineering. Together with management experience, and a team-centric and inspiring attitude, you will be an excellent addition to our exciting team of committed scientists.POSITION ACCOUNTABILITIES:

  • Demonstrates outstanding experience and expertise, depth and breadth of knowledge in the field of antibody and protein engineering, directed evolution and drug discovery.
  • Bring significant years of experience with an industry style mindset to deeply mine repertoires and progress programs for therapeutic applications. Sharing expertise and knowledge to mentoring and grow the overall team experience.
  • Draws on expertise from in vivo based discovery platforms, including variety of immunization strategies for transgenic animals and isolation of specific antibodies using single B cell technologies.
  • Brings deep understanding of B cell biology, humoral immunity, immunoglobulin genetics, isolation of antigen specific B cells from in vivo sources.
  • Thoughtfully design and implement successful in vivo antibody discovery campaigns in species including human transgenic animals and llamas for a range of target types including difficult GPCR based targets.
  • Lead the team to build out and further optimize the B cell cloning platform using both FACS and Berkeley Lights Beacon technologies for VHH and IgG based workflows. This includes integration protocols to enable fast and efficient lead discovery.
  • Help drive establishment of NGS related workflows for both discovery and quality control of library generation within the team.
  • Ambassador for the Global Biologics Department through serving as biologics lead, scientifically inputting to the project teams, proposing discovery and optimization plans, leading the biologics aspects of the program while overseeing and driving forward.
  • Contributes to continual deepening of the expertise through external network development, evaluating new opportunities in partnership with business development.
  • Organizational leader who has accountability for the performance and results of this significant research function.
  • Empowerment to lead a small team of highly qualified and skilled scientists in their mission to generate therapeutic biologics, with many programs in multi-specific formats.
  • Team-centric mindset, a leader that can inspire and grow team members, while serving as a role model and mentor across the entire team.
  • Develops the next-generation of organization and project leaders, acting as a champion of new opportunities.
  • Responsible for effective resourcing within team to drive programs forward in and efficient manner.
  • Excellent knowledge of data analysis tools to ensure thorough evaluation of datasets and information based next step decisions.
  • Lead team through in-lab presence, designing and efficiently executing discovery /optimization campaigns including affinity maturation, developability; technology development.
  • Serve as an effective lead and ambassador for biologic discovery programs, collaborate and interact with team members and internal/ external groups for high efficiency and transparency to enable progression of molecules.
  • Identify areas to improve efficiency, technology development to bring new innovation to the team, where appropriate.
  • High level of diligence in all data tracking, uploading and recording using data management systems within the department.
  • Independently manage workload, while designing, develop and execute research assignments and contribute to multiple projects in parallel.
  • Initiate and lead external interactions, collaborations and workflows where appropriate.
  • Contribution to the preparation of patents, documentation for IND, and publications.EDUCATION, BEHAVIORAL COMPETENCIES AND SKILLS:
    • PhD in a scientific discipline (7+ years' experience), or MS (13+ years' experience) or BS (15+ years' experience) in Immunology/Cell Biology/Biochemistry or related fields.
    • 5 years of industry experience required in antibody discovery in a biotech/pharma setting.
    • 5 years of managerial experience required.
    • Exceptional knowledge of in vivo antibody discovery coupled with B cell cloning, and engineering.
    • Excellent familiarity with antibody repertoire analysis- NGS data handling and analysis.
    • Track record of progressing programs forward with industry mindset.
    • Experiences with multi-specific antibody modalities is preferred.
    • Knowledge of modalities such as engineering for cell and gene therapy is preferred.TRAVEL REQUIREMETS:
      • Attend scientific meetings or conferences on a yearly basisWHAT TAKEDA CAN OFFER YOU:
        • 401(k) with company match and Annual Retirement Contribution Plan
        • Tuition reimbursement Company match of charitable contributions
        • Health & Wellness programs including onsite flu shots and health screenings
        • Generous time off for vacation and the option to purchase additional vacation days
        • Community Outreach ProgramsAbsent an approved religious or medical reason, all US office-based and lab-based Takeda employees who work fully on-site or in a hybrid model (as determined by Takeda) must be fully vaccinated to work at a Takeda site or to engage with Takeda colleagues or anyone else on behalf of Takeda. US field-based employees must be fully vaccinated as a condition of employment, absent an approved religious or medical reason. US employees who work at a Takeda manufacturing facility, and those who work at a BioLife center or BioLife lab, may be subject to different guidelines. If you are contacted by a Takeda recruiter about your job application, we encourage you to seek more information on the applicable guidelines for the Business Unit/Function to which you have applied.Empowering Our People to ShineDiscover more at takedajobs.comNo Phone Calls or Recruiters Please.This job posting excludes CO applicants.#LI-SGMEEO StatementTakeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law.LocationsBoston, MAWorker TypeEmployeeWorker Sub-TypeRegularTime TypeFull time

Keywords: Takeda Pharmaceutical, Mount Vernon , Principal Scientist / Associate Director for Antibody, Biologic Discovery & Engineering, Engineering , Mount Vernon, New York

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